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New single-cell sequencing method has the potential to boost efforts to find cancer-fighting drugs. Most cancerous tissue consists of rapidly dividing cells with a limited capacity for self-renewal, meaning that the bulk of cells stop reproducing after a certain number of divisions. However, cancer stem cells can replicate indefinitely, fuelling long-term cancer growth and driving relapse. Cancer stem cells that elude conventional treatments like chemotherapy are one of the reasons patients initially enter remission but relapse soon after. However, cancer stem cells are difficult to isolate and study because of their low abundance and similarity to other types of stem cell. This has hampered international research efforts to develop precision treatments that target malignant cells while sparing healthy ones. Researchers from EMBL and the Centre for Genomic Regulation CRG in Barcelona have overcome this problem by developing a method called MutaSeq, which can be used to distinguish between cancer stem cells, mature cancer cells, and otherwise healthy stem cells based on their genetics and gene expression patterns.
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Complete streets is a transportation policy and design approach that requires streets to be planned, designed, operated and maintained to enable safe, convenient and comfortable travel and access for users of all ages and abilities regardless of their mode of transportation. Complete Streets allow for safe travel by those walking , cycling , driving automobiles, riding public transportation , or delivering goods. The term is often used by transportation advocates, urban planners , traffic and highway engineers , public health practitioners, and community members in the United States and Canada. Complete Streets are promoted as offering improved safety, health, economic, and environmental outcomes. Complete Streets emphasize the importance of safe access for all users, not just automobiles.