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The Stegle group develops advanced statistical approaches for unravelling molecular variation at a genome-wide scale and applies them to systems genetics and oncology. Our interest lies in computational approaches for unravelling the genotype-phenotype map on a genome-wide scale. How do genetic background and environment jointly shape phenotypic traits or cause diseases? How are genetic and external factors integrated at different molecular levels, and how variable are these molecular readouts between individual cells? We use statistics as our main tool to answer these questions.
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