Many insults expose the entire lung to damage either because the inciting agent is airborne or because the inciting agent is bloodborne. However, it is readily apparent from radiographs that although the insult may be diffuse, the pathologic response rarely is. Asbestosis, worse in the lower lobes, or silicosis, worse in the upper lobes, are only two examples of this phenomenon. The immediate question is: if the insult affects the entire lung, why is the distribution nonuniform?
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