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Researchers from EMBL and Heidelberg University Hospital combine high-resolution imaging to observe the infection process in cell nuclei, opening the door for new therapeutics. The electron tomographic images show the protein envelope of the virus passing through one of the nuclear pores — the openings in the membrane around the nucleus that allow molecules in and out. The scientists found that the virus passes through the nuclear pore intact, only breaking apart inside the nucleus, where it releases its genetic information. The genetic material of the virus is securely packaged in a cone-shaped protein capsule known as the capsid, which is composed of individual hexagonal parts. This is where the work of the Heidelberg collaboration comes in.