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One of the ways that alcohol can affect the brain is by damaging the functioning of serotonin , a chemical that influences mood, sleep, appetite, temperature regulation, and mood. Consequently, people with alcohol use disorders often report problems with depression and anxiety. In the brain, serotonin is thought to influence mood, emotions, sleep, appetite, and temperature regulation. Research has found, however, that SSRIs —such as sertraline Zoloft —do not work well for some people with alcohol use disorders. To determine why SSRIs help some patients with alcohol use disorders and not others, Dundon and his colleagues examined two categories of alcohol dependence defined by researcher Thomas Babor of the University of Connecticut.